Placental ischemia and soluble fms-like tyrosine kinase 1: Cause or consequence of preeclampsia?
نویسندگان
چکیده
منابع مشابه
Prediction of Preeclampsia Using the Soluble fms-Like Tyrosine Kinase 1 to Placental Growth Factor Ratio
We sought to assess the ratio of sFlt-1 (soluble fms-like tyrosine kinase 1) to PlGF (placental growth factor) in maternal serum as a screening test for preeclampsia in unselected nulliparous women with a singleton pregnancy. We studied 4099 women recruited to the POP study (Pregnancy Outcome Prediction) (Cambridge, United Kingdom). The sFlt-1:PlGF ratio was measured using the Roche Cobas e411 ...
متن کاملDifferential diagnosis of preeclampsia: remember the soluble fms-like tyrosine kinase 1/placental growth factor ratio.
P reeclampsia is a pregnancy-associated condition, clinically characterized by hypertension, proteinuria, and progressive edema, affecting 3% to 5% of all pregnancies. 1 Preeclampsia can occur in previously healthy women and in women with underlying conditions, such as hypertension, lupus nephri-tis, or the antiphospholipid syndrome (APS). 1,2 Conversely, pregnancy can be a trigger to activate ...
متن کاملClinical Usefulness of Soluble Fms-like Tyrosine Kinase 1, Soluble Endoglin and Placental Growth Factor in Korean Women with Preeclampsia
Results The mean serum level of sFlt-1 and sEng in women with preeclampsia was significantly higher than normal pregnancy. But the mean serum level of PIGF had no signifi cant difference between two groups. The cut-off values of sFlt-1 and sEng showing differential signifi cance were 26.3 ng/mL and 21.1 ng/mL each. Then the sensitivity, specifi city, positive predictive value, negative predicti...
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It has not been clarified whether thresholds of soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PlGF), soluble endoglin, and the sFlt-1/PlGF ratio for the imminent onset of preeclampsia (PE) exist. We hypothesized that onset thresholds for the imminent onset of PE could be determined by the distributions of these 4 markers just after the onset of PE. Study subjects were 51...
متن کاملPlacental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia
Preeclampsia (PE), an important cause of maternal and perinatal morbidity and mortality worldwide, is a pregnancy-related disease characterized by hypertension and proteinuria after 20 weeks of gestation. The aim of our study was to find a practical panel of biomarkers useful in early diagnosis of PE. This study was carried out at the Obstetrics and Gynecology Department in Tîrgu Mureș Universi...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2007
ISSN: 0085-2538
DOI: 10.1038/sj.ki.5002281